Nódulo angiomatoso epitelioide cutáneo. ¿Variante superficial y extrafacial de hemangioma epitelioide? / Cutaneous epithelioid angiomatous nodule. Is it a superficial and extrafacial variant of epithelioid hemangioma?

El nódulo angiomatoso epitelioide cutáneo (NAEC), esuna lesión vascular recientemente descrita que muestrahallazgos histológicos distintivos y un curso evolutivobenigno. Clínicamente suele presentarse como un nódulo opápula eritematosa de reciente aparición, predominantementelocalizados en tronco y extremidades; y a pesar, delas aparentes diferencias clínico-patológicas, no es posiblecon certeza descartar que pueda tratarse de una variantepoco usual de hemangioma epitelioide (HE)

Cutaneous epithelioid angiomatous nodule (CEAN), is arecently described vascular lesion with distinct histologicalfeatures and apparently benign behaviour. The lesion is predominantlylocated in the trunk and extremities. It appearsas a small erythematous papule or nodule with a short history.Despite the apparent clinicopathologic differences, thepossibility that CEAN represent a very unusual variant ofepithelioid hemangioma can not absolutely be excluded

Adenoma tubular con diferenciación e inmunofenotipo anexial divergente (hidradenoma túbulo-papilar) / Tubular adenoma with adnexal divergent differentiation and immunophenotype (tubulopapillary hidradenoma)

Hidradenoma túbulo-papilar (HPT) es el término propuestopara designar tumores ductales dérmicos con diferenciacióndivergente ecrina y apocrina, englobando unespectro de lesiones que incluye adenoma tubular apocrino(ATA) y adenoma ecrino papilar (AEP).Presentamos un caso de HPT localizado en la pierna deuna mujer de 81 años de edad. El perfil inmunohistoquímicodemostró la coexistencia de inmunofenotipos secretoresapocrino y ecrino

Tubulopapillary hidradenoma (TPH) is a term describingdermal ductal tumors with both eccrine and apocrinedifferentiation, encompassing a spectrum of lesions includingtubular apocrine adenoma and papillary eccrine adenoma.We report a case of a TPH in a 81-years-old womanlocated on the leg. The immunohistochemical profile revealedthe coexistence of eccrine and apocrine secretory immunophenotypes

Hemangioma elastótico adquirido ¿Una entidad infradiagnosticada? / Acquired elastotic hemangioma: an underrecognized entity?

Planteamiento: Describimos una variante clínicopatológica de hemangioma adquirido que aparece en el adulto y que probablemente sea una entidad infradiagnosticada. Material y métodos: Este artículo informa sobre los hallazgos clínicos, histológicos e inmunohistoquímicos de una variante de hemangioma cutáneo llamada hemangioma elastótico adquirido. Resultados: El hemangioma elastótico adquirido se presenta en la piel con daño actínico como placas eritematosas con una apariencia angiomatosa. Histológicamente muestra una proliferación en dermis superficial de capilares que se disponen paralelos a la epidermis. Conclusiones: El hemangioma elastótico adquirido es una variante clínicopatológica de hemangioma diferente de otras proliferaciones vasculares cutáneas (AU)

Benign fibrous histiocytoma with indeterminate cells and eosinophils: collision, differentiation, or involution?

This report describes the clinicopathologic, immunohistochemical, and ultrastructural features of a benign fibrous histiocytoma of 3 years' duration situated on the posterior right arm of a 17-year-old woman. To our knowledge, this is the first published description of an association between the histologic features of benign fibrous histiocytoma with proliferating dermal dendrocytes and solid clusters of indeterminate cells and inflammatory infiltrate containing numerous eosinophils. Cell type identification was confirmed by immunohistochemical demonstration of positivity of indeterminate cells for CD1a and S-100 protein, by absence of Birbeck granules in electron microscopy study, and by positivity of fibroblast-like cells for factor XIIIa and negativity for CD34. Mitosis or cytologically atypical cells were absent. The MIB1-measured proliferative index of the tumor cells was less than 5% in spindle cells and approximately 15% in indeterminate cells. Possible pathogenic pathways are discussed that could account for divergent differentiation or a combination of neoplasms of different lineages.